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For patients pursuing systemic regenerative or wound-healing protocols, injectables have a legitimate role under physician supervision, but if you are asking about wrinkles, skin firmness, or hair thinning, topical is the right delivery method

Its anti-inflammatory effect includes decreasing levels of inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), making it a potential anti-inflammatory agent

10.1126/science.1846706 Science

L-ascorbic acid (the most potent form of topical vitamin C) requires a low pH, typically around 2.5 to 3.5, to remain stable and penetrate the skin

For instance, BPC-157 is touted for healing many types of injuries from [those of the] tendons and muscles to the gut and brain, says Kumar