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Secondary areas include cardiovascular protection and organ protection in toxicity models
S.KesslerC
26 Furthermore, DUL ameliorated LPS-induced oxidative stress in H9c2 myocardial cells, 22 and attenuated TNF--induced oxidative stress in human fibroblast-like synoviocytes, 28 because incretin-based therapy was found to exert antioxidant effects through the upregulation of renal Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), which augments the transcription of antioxidant enzymes that scavenge free radicals, indeed Nrf2 is a major regulator of oxidative state, enhancing cellular defenses against oxidative damage by upregulating the transcription of antioxidant enzymes
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doi:10.1371/journal.pone.0103982 Chiang KC, Sun CC, Chen MH, Huang CY, Hsu JT, Yeh TS, Chen LW, Kuo SF, Juang HH, Takano M et al (2016) MART-10, the new brand of 1alpha,25(OH)2D3 analog, is a potent anti-angiogenic agent in vivo and in vitro
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