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Key findings: Higher suicide risk was associated with greater day-to-day stability not chaotic, but pathologically stuck states During active suicidality, mood and energy became uncoupled a potential digital signature of risk Even in euthymia, prior risk was linked to persistent moodanxiety dysregulation remission absence of risk Takeaway: Suicide risk may be less about intensity of symptomsand more about how rigidly internal states evolve over time

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Studies have shown that topiramate can be nearly as effective for weight loss as phentermine combined with topiramate over a 1-year period 5.1.5 Effectiveness After GLP1 Therapy While no large-scale clinical trials specifically examine topiramate for post-GLP-1 maintenance , indirect evidence is compelling: Studies have shown topiramate produces 510% weight loss as monotherapy, with less weight regain over time

Further research is needed to fully understand the relationship between semaglutide and NAION risk