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The median treatment duration was eight weeks, during which participants taking the tricyclic antidepressant maprotiline experienced a mean weight gain of 1.82 kg, while those on agomelatine experienced a mean weight loss of 2.44 kg
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Perturbations of this axis, such as oral dysbiosis or compromised barrier function, have been increasingly implicated in the pathogenesis of diverse systemic diseases, which involve three key mechanistic pathways of how localized oral events could exert distant effects ( Table 1 )
CAS Number: 173686-73-2
