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Melatonin supplementation alone, though, wasnt enough to return the AD mice to normal control levels, but the improvements were significant.[ref][ref][ref][ref] Another study using a mouse model of AD found that melatonin reduced the signs of Alzheimers, including cognitive deficits

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The oxidative status has been previously analyzed in PKAN fibroblasts [18]

Moreover, although GSH can cross OMM, its transport into mitochondrial matrix cannot be explained by simple diffusion