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Long-term safety and cardiovascular outcomes are not yet established no completed cardiovascular outcomes trial exists as of 2026 and dose-dependent increases in heart rate were observed in Phase 2, a class effect under continued study

Originally developed to treat type 2 diabetes, they have become the go-to prescription for weight management thanks to their rapid effects, and nearly one in five American adults (18%) 2 have taken them at some point, with a further 35% expressing interest 3

Hello100 is an over-the-counter supplement, not FDA-reviewed for efficacy

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Sexual function through MC4R activation in the brain