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Insulin receptors are expressed on hypothalamic neurons, predominantly in ARC (158)

It plays a crucial role in the transport of fatty acids into the mitochondria of cells, where they are converted into energy

If we recall that approximately 25% of total weight loss in persons with obesity is accounted for by FFM, the authors found that fat free mass accounted for 33%, 39%, and 25% of total weight loss for retatrutide ( Phase 2 data only, not yet FDA approved), semaglutide and tirzepatide respectively whereas fat mass loss accounted for 67%, 61%, and 75% respectively

Lilly is also developing a triple G drug, which additionally targets glucagon

Tirzepatide: dual-pathway incretin research compound with broad vial-size coverage