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This mechanism was documented in humans in 1984 by Bowers and confirmed in multiple clinical studies (Nass et al., J Clin Endocrinol Metab 2008)
Thethi TK, Pratley R, Meier JJ
Regain begins within 4 to 6 weeks of last dose Appetite increases but remains below pre-treatment baseline Weight regain of 0.5 to 1 pound per week for 12 to 16 weeks, then plateau Patients report maintaining some dietary changes learned during treatment Net long-term outcome: retain 30 to 50% of weight lost on medication Typically occurs in patients who built structured meal patterns and exercise habits during treatment Pattern 3: Sustained maintenance without medication (approximately 15% of discontinuations)
* Long-Lasting Delivery Designed to provide stable, gradual absorption for extended metabolic and appetite support
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