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Within the geroscience framework 16 , the accelerated-aging phenotype in PWH provides an ideal clinical model to evaluate candidate geroprotective therapies, with findings potentially relevant to the general aging population
Zhang, M.L., and Johnson, R.T
Tirzepatide (Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
These results were from part one of the ongoing ESSENCE trial, a pivotal phase III, 240-week, trial in 1,200 adults with MASH and moderate to advanced liver fibrosis (stage 2 or 3)
Dose adjustment, temporary treatment interruption, or switching to an alternative therapy may be appropriate
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