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By activating both pathways, a dual agonist can produce a more powerful effect on appetite suppression and metabolic function than a GLP-1 agonist alone

Whilst this represents a relatively short time in pharmaceutical terms, the medication has generated substantial clinical interest due to its novel dual-action mechanism and efficacy data from pre-approval studies

Patients must remain on this introductory 2.5 mg dose once weekly for exactly 4 weeks to establish gastrointestinal tolerance before escalating to the 5 mg weekly dose

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Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: a two-sample Mendelian randomization analysis of European and East Asian populations