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When two compounds share a final therapeutic outcome (tissue repair) but achieve it through different receptors and cellular intermediaries, their combination can produce effects that exceed what either compound delivers alone without requiring dose escalation of either component
Role of microglia after subarachnoid hemorrhage
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This resulted in a pooled incidence rate of 2.1 per 1,000 patient years for the GLP-1 receptor agonists compared with 1.5 per 1,000 patient years for the comparators
