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This score is calculated deterministically from the forms own structure using Instafills published Form Complexity Index methodology, so it can be reproduced and independently verified it is not a subjective estimate
A drug-induced depression may not run on a mainly serotonergic mechanism, so an agent with a wider receptor footprint (SERT inhibition plus 5-HT1A agonism, 5-HT3 and 5-HT7 antagonism, and 5-HT1B partial agonism) looked better matched to the uncertainty about what was actually driving the episode
This study design gave the needed statistical analysis to trust the results
10.1007/s00125-017-4450-9 52
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