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At higher doses used specifically for weight management (Wegovy 2.4mg or experimental high-dose oral semaglutide), people typically lose about 15% of their body weight over 68 weeks
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That year Charles Kimball, a biochemist, and John Murlin, a physiologist, at the University of Rochester in New York, isolated a substance in the duodenal and pancreatic mucosa of dogs that raised blood sugar levels in depancreatised dogs
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Preclinical studies using native GLP-1 or GLP-1RA have provided convincing evidence of its cardioprotective benefits, while clinical trials have shown positive effects on hypertension and dyslipidemia in patients with T2DM [3]
