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Vesicular glutamate transporters have a much lower affinity for glutamate 0.5-3.5 mM than plasma membrane transporters GLT1/EAAT2, whose Km is 4-40 M (25, 26)
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TLR1, TLR2 and TLR4 activation results in augmented mitochondrial ROS production following recruitment of mitochondria to macrophage phagosomes, leading the way to increased mitochondrial and cellular ROS generation (West et al., 2011)
B12 is water-soluble, so excess amounts are excreted in urine
Some causes of earwax impaction include hair in the external auditory canal, increasing age, and use of cotton swabs
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