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Single molecule activates GLP-1, GIP and glucagon receptors simultaneously Albumin-binding domain for extended pharmacokinetic half-life Covalent linkage resistant to retro-Michael addition (avoids decoupling) Follows clinical validation of dual and triple agonists in metabolic disease The inventors of this patent are Patrick Soon-Shiong , Martin Robitaille , Bing Song from Albunext LLC

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GLP- 1 Receptor Agonists in Development Orforglipron is an oral, non-peptide, small molecule glucagon-like peptide- 1 receptor agonist [104]