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thus, dysregulation of iron metabolism might serve as the initial trigger of ferroptosis
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Auto-Abs are a central characteristic of the disease, in particular IgG, binding various nuclear/intracellular antigens related to the protein-RNA complex formed by Ro60 and La/SSB proteins [191,192,193,194], which are commonly referred to as anti-Sjgrens syndrome-related antigen A or anti-Ro and/or anti-La (the Ro and La nomenclature arises from the name of patients from which the antigens were initially characterized [195]) Abs [196, 197]
In a separate apoptotic pathway, TNF-induced cell death involves early caspase-9 activation that occurs independently of cytochrome c
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