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Using genetically modified mouse models for targeted disruption of AR gene, we and others have shown that AR is essential for bone mineralization [22, 23] and deficiency of AR signaling in bone marrow mesenchymal stem/progenitor cells (MSCs) leads to increased adipogenesis, decreased osteogenic differentiation, and subsequent age-related bone loss [24, 25]
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Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes
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