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Mosenzon et al
Many patients transition to a lower maintenance dose over time
Perspective RWS confirm the transferability of results seen in RCTs to populations less represented in these trials, such as the elderly or non-obese individuals or those with diabetic kidney disease
However, the side effects of long-term use of metformin in the patients with PCOS should not be ignored, which include gastrointestinal reactions, neurological adverse reactions, hypoglycemia, metabolic problems, and so on
An animal study reported that L-carnitine supplementation markedly reduced the concentrations of TNF-, IL-1b, and CRP in Wister rats
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