4.2 Stimuli-responsive nanoplatforms for spatiotemporal drug release The TME of osteosarcoma exhibits distinct physicochemical features, including acidic pH, elevated glutathione levels, and hypoxia, that can be exploited for stimuli-responsive drug release (45, 59)
Glutathione is generally considered safe across all Fitzpatrick skin types (I through VI)
However, three safety concerns warrant attention
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