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In some research contexts, higher doses have been explored, but those studies involve close medical monitoring that is a far cry from someone self-administering based on a chart they found in a Facebook group

Tirzepatide, a dual GIP/GLP-1 receptor agonist, has a slightly different receptor activity profile and may be tolerated differently, though gastrointestinal side effects remain common

Monami et al

Thats why its recommended to rotate the injection site each week

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