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-Glutamylcysteine synthetase and GSH increase in quinone-induced oxidative stress in BPAEC

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The T4 is subsequently deiodinated by the Selenium dependent enzyme, Iodothyronine, deiodinase

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In parallel, clinical translation should incorporate mechanistic biomarkers and patient stratification to balance efficacy and safety, enabling the identification of subgroups most likely to benefit from ferroptosis-targeted interventions