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Age-related changes in intestinal function may also affect GLP-1 production, though evidence remains limited

GLP-1 microdosing refers to using a significantly lower dose of a GLP-1 medication than the FDA-approved schedule, often to minimize side effects while still achieving some metabolic benefit

cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act in concert to generate downstream signals resulting in increased insulin secretion 8

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Karacabeyli, D