what should i eat when taking semaglutide Foods Patients or Avoid Medications? What to Eat on GLP-1

Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). New England Journal of Medicine

Others are temporarily converted into reactive intermediates that must be rapidly neutralized by glutathione or another conjugation pathway

It can trigger a cascade of downstream events (like gene activation or protein synthesis) that continue long after the peptide itself has been degraded

Washout approach (more common): Administer final Wegovy dose Wait 7 to 10 days (approximately 1.5 half-lives) Start Zepbound 2.5 mg Rationale: minimizes overlapping GLP-1 receptor activation, reduces nausea risk Overlap approach (less common, used when continuous appetite suppression is critical): Administer final Wegovy dose Start Zepbound 2.5 mg 3 to 4 days later Rationale: prevents gap in therapeutic effect during washout Risk: higher nausea and GI side effect burden during overlap window Most providers use washout

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