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Furthermore, the initial phase of rapid weight loss often coincides with the period when side effects like nausea or fatigue might be most pronounced 31 , potentially hindering a person's ability to start or maintain consistent strength training and ensure adequate protein intakethe very strategies needed to protect muscle

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Appetite and Metabolic Effects Retatrutide may support greater energy expenditure compared with tirzepatide

Accessed May 8, 2026

p = 0.02), and the 50% responder rate was 76.9% vs