Where GLP-1 and GIP work mostly on the input side (eating less, feeling full sooner, processing food differently), glucagon works on the output side (burning more energy and clearing fat from the liver)
The good news is that GLP-1 Revenue concentration is declining down from 41% in Q4 2024 to 24% in Q4 2025 so if the GLP-1 business were shut down, the impact would be less severe
The role of the NRF2 pathway in maintaining and improving cognitive function
Rey F, Berardo C, Maghraby E, Mauri A, Messa L, Esposito L, Casili G, Ottolenghi S, Bonaventura E, Cuzzocrea S, Zuccotti G, Tonduti D, Esposito E, Paterniti I, Cereda C, Carelli S (2023) Redox imbalance in neurological disorders in adults and children
This is not an exhaustive review of the numerous suggested benefits of MOTS-c peptide therapy in ongoing clinical analysis