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5 Moreover, GLP-1 RAs have demonstrated cardioprotective properties that are independent of weight loss by reducing the content of systemic inflammation markers
6 The mean change in weight at week 72 was shown to be 20.2% with terzepatide and 13.7% with semaglutide
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Critically, these effects were achieved without food intake suppression, distinguishing MOTS-c from GLP-1 receptor agonists whose primary mechanism involves appetite reduction
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