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As the residue identity between MPGES1 and MGST1 is partly high for the TM1-TM2 loop (in this cytoplasmic loop, 5 out of 8 residues among K42-D49 are conserved between MGST1 and MPGES1), it may be the case also for MGST1 that this loop is not directly involved in GSH binding but serves other purposes

Activation of UQCRC2-dependent mitophagy by tetramethylpyrazine inhibits MLKL-mediated hepatocyte necroptosis in alcoholic liver disease

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However, how this happens is not completely understood

All equipment is sterile and single-use