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Neuroprotection in the Central Nervous System Glutathione (GSH) plays a vital neuroprotective role in the central nervous system (CNS), primarily by regulating redox homeostasis, detoxifying electrophilic compounds, and modulating excitotoxic signaling pathways

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guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g