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One intriguingbut speculativepossibility is that GSSG might paradoxically protect the ER by exacerbating protein misfolding, if doing so renders misfolded client proteins more readily recognized and either refolded or cleared rather than futilely engaged with the ER quality control machinery
The levels of glutathione in the cells of the human body begin to decline after the age of twenty
Ledowsky C, Mahimbo A, Scarf V, Steel A
L.Tom-CarneiroJ.Gil-CabrerizoP.San-CristobalR.BustoR.et al (2021)
Helli B, Gerami H, Kavianpour M, Heybar H, Hosseini SK, Haghighian HK
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