Lack of Long-Term Data: While Semaglutide shows promise, more long-term studies are needed to fully understand its effects on kidney health, especially in individuals with advanced kidney disease
There is also a small risk of kidney injury if severe vomiting, diarrhea, or dehydration occur
Under the brand name Zepbound, the same molecule is approved for weight loss in adults
Patients should contact their healthcare provider if gastrointestinal side effects do not improve after 68 weeks at a stable dose, as this may indicate poor tolerance requiring dose adjustment or medication discontinuation
Within this inflammatory milieu, a complex network of pro-inflammatory cytokines, chemokines, and immune cells orchestrates activities that promote tumor cell proliferation, angiogenesis, and immune evasion [8,9,10]