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The ETF is localized to the inner mitochondrial membrane where it accepts electrons from the FAD-dependent dehydrogenases of mitochondrial fatty acid -oxidation as well as several dehydrogenases involved in amino acid metabolism
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Patient Education Medication guidance: Provide detailed instructions on the injection method, dosage and possible side effects
Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients
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