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may progress to hemorrhagic shock Tachypnea compensatory respiratory response Decreased urine output in hypovolemic states from acute blood loss Koilonychia (spoon nails) and glossitis classic signs of chronic iron deficiency anemia Pica craving for non-food items (ice, clay, dirt) seen in severe iron deficiency Polycythemia Pruritus after bathing (aquagenic pruritus) characteristic of polycythemia vera

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Two further cautions: Coskun 2018 measured tirzepatide GIPR EC50 at 0.0224 nM in a standard-density system, 45 more potent than Willards low-density figure, which is why standard-density values cannot be mixed into this comparison

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