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All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes

2023;24(1):e13325

Patients should be closely monitored for any adverse reactions, and dosages may be adjusted depending on individual response and tolerance

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Both tocotrienols and tocopherols are divided into -, -, -, and -based on the hydroxyl and methyl substitution in their phenolic rings [48]