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The primary concerns include additive cardiovascular effects (both can increase heart rate), excessive appetite suppression leading to inadequate nutrition, and potential gastrointestinal side effects

Additionally, patients should consider their work schedule and social commitmentschoosing a time when they can comfortably manage potential side effects without disrupting important activities

Expanding that framework, or developing alternatives that achieve similar outcomes for the commercially insured population, will require policy innovation that moves faster than the current rate of change