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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

Metabolic effects of social isolation in adult C57BL/6 mice (in Eng)

Increased fatty-acid availability is not identical to increased oxidation

Microbial changes and host response in F344 rat colon depending on sex and age following a high-fat diet (in Eng)

The fat-loss benefit persists as long as caloric discipline and training continue