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Some studies have identified metabolic deficiencies in autistic children [14], and it has recently been shown that there is a characteristic metabolic profile in many autistic children involving disturbances in methionine and glutathione metabolism [14, 15]

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Previous work has revealed that mild oxidative stress may induce S-glutathionylation of signal transducer and activator of transcription 3 (STAT3), leading to the suppression of the STAT3 pathway, downregulation of STAT3-dependent gene expression and chemosensitization of tumor cells to chemotherapy (42)

J Biol Chem 283: 21347-21361 Dowdle J, Ishikawa T, Gatzek S, Rolinski S, Smirnoff N (2007) Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability