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Patient selection considerations include: Adults with BMI 30 kg/m or 27 kg/m with weight-related comorbidities [1] [7] Contraindications must be carefully reviewed, including personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis, gallbladder disease, severe gastrointestinal disease, or renal impairment requires caution Not recommended during pregnancy or lactation Clinicians should counsel patients that while inflammatory marker improvements have been observed in research settings, Zepbound is prescribed for weight management, not inflammation treatment

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While those drugs target one or two receptors (GLP-1 and GIP), Retatrutide activates three key receptors: GLP-1: Suppresses appetite and improves insulin sensitivity

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Pancreatitis (inflammation of the pancreas): If you have severe stomach (and sometimes back) pain, with or without vomiting, stop taking Semaglutide and contact your prescriber