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A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron
Some individuals feel changes within days at the starting 0.25mg dose, while others need several weeks at 0.5mg or higher before experiencing significant appetite reduction
Unlike subcutaneous fat, visceral fat is biologically active
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