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In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)

Major histocompatibility complex susceptibility genes, including HLA-DR3, HLA-DR4, HLA-DQ2, and HLA-DQ8, are shared by both diseases

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