Each shows cumulative temperature breaches of over 8C over 1-4 weeks, and also show a low temperature alert at 2C, alerting healthcare professionals and patients to the danger of freezing
1 The cross-trial caveat applies here
For me it wasnt a big weight change either way because its never been my challenge
In October, Eli Lillys Zepbound and Mounjaro were removed from the drug shortage list after nearly two years, though the FDA warned that there still may be intermittent localized supply disruptions. The removal from the listwhich bars outsourcing facilities from producing compounded versionsspurred the Outsourcing Facilities Association to file a lawsuit against the FDA, saying the move will deprive much of the public of access to a needed medicine. In response, the FDA agreed to reevaluate the situation and will allow compounding to continue during this period
Why the Comparison is Still Incomplete This is the part many summary articles skip: no direct randomized head-to-head trial is currently available in the published literature comparing retatrutide with tirzepatide on the same protocol, in the same population, over the same duration