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mean duration of type 2 diabetes, 14.9 years)
Venetoclax resistance has become increasingly evident as research progresses, primarily due to dysfunction in pro-apoptotic mechanisms and the upregulation of compensatory anti-apoptotic proteins, such as myeloid cell leukemia-1 (MCL-1)
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CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability
Primary antibodies, anti-Ki 67 (#sc23900, Santa Cruz Biotechnology, USA) and anti-phospho IRE1 alpha (p-IRE1) (#AF7150, Affinity Biosciences, USA) were applied at a 1:100 dilution for 3 h at RT
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