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A trial in adults without diabetes can produce different weight-loss results than a trial in adults with type 2 diabetes
This is due to cumulative damage to mitochondrial DNA which would otherwise have been reduced by glutathiones antioxidant activity and protective effects
AMPK activity counteracts the negative effects of mTOR and NF-kB (Wang et al., 2020)
These monotherapy results established proof of concept that amylin receptor agonism alone can produce clinically meaningful weight reduction and informed the dose selection of 2.4 mg for the combination product CagriSema
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