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It is crucial to note, however, that recent studies highlight significant systemic side effects of MCT4 inhibition due to its broad tissue expression, which may limit its clinical translational potential and necessitate the development of tissue-specific delivery strategies [138]
A study found that significant increases in the expression of GPX4 and sensitivity to ferroptosis in ACCs, suggesting that inducing ferroptosis may be a promising approach for the treatment of ACCs
Treatment with Dihexa at doses of 1.44-2.88 mg/kg administered intragastrically for three months significantly reduced escape latency and increased time spent in the target quadrant during probe trials
Poupon, R
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