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Physiol Rev 99, 2178
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Both Heffernan papers showed significant reductions in body weight gain, increased fat oxidation measured by indirect calorimetry, and elevated plasma glycerol (a marker of active lipolysis) in obese mice
Around 70% of hepatocytes were lost early after transplantation due to neutrophil and macrophage/monocyte infiltration elicited by complement activation and cytokine release ( Complement system initializes innate immune system activation and shares a crosstalk with coagulation system
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