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Metformin and phentermine are among the cheapest options

If nausea or other GI side effects persist beyond 4-6 weeks despite dose stabilization, provider guidance should address whether to continue, adjust the formulation, or transition to an alternative

Trends Endocrinol Metab 32:890903 Armstrong CW, McGregor NR, Lewis DP et al (2015) Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients

This dual action has made it a leading candidate for investigating complex metabolic mechanisms

Headache is reported by approximately 1015% of patients and usually resolves within the first month of therapy