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Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides
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Fu SQ, Consoli U, Hanania EG, Zu Z, Claxton D, Andreeff M , Deisseroth AB
Bull Environ Contam Toxicol 107:924930
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