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Arsenic and chromium induced toxicity on zebrafish kidney: mixture effects on oxidative stress and involvement of nrf2-keap1-are, DNA repair, and intrinsic apoptotic pathways

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Cell Physiol Biochem (2017) 44(5):1696714

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The substitutions reportedly occur at the 2nd, 8th, 15th, and 27th amino acid residues, modifications thought to support stability against proteolytic degradation and improve receptor interaction