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Macrophage subsets (MAC.1, MAC.2) were distinguished by high expression of CD68, CEBPB , and FCER1G , while a third cluster (Inf.MAC) expressed NLRP3 and showed an inflammatory, cytokine-enriched, and pro-angiogenic profile with markers like IL1B and CCL3

This lifts the subcutaneous fat away from the underlying muscle

In the HOPE-K group, one patient receiving double KT was matched with 3 double KT cases in the control group

Patients may need more treatment if their voice changes or they have problems breathing or swallowing

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