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This reduction in systemic inflammation has downstream effects on energy, mood, and cognitive function

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Referral to specialist weight management services may be appropriate for individuals with higher BMIs who have not achieved adequate weight loss through lifestyle measures alone, with thresholds typically around BMI 40 kg/m or 35 kg/m with significant comorbidities (with lower thresholds for people from certain ethnic groups), though local pathways may vary

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But they also represent one of the most significant cost risks to employer health insurance plans heading into the 2026 renewal cycle