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[33] In February 2018, authorization was granted in the European Union, [16] [86] in March 2018 in Japan, [34] and in August 2019 in Australia
This increased sensitivity means that minor elevations in core body temperature can trigger inappropriate heat-dissipation responses, manifesting as hot flashes
Over-dosing frequency without mechanistic justification adds cost, increases injection site trauma in animal models, and complicates circadian confounding variables without improving endpoint sensitivity
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